Vitamin B1 Thiamine Function & Deficiency disease

Vitamin B1 is one of the 8 vitamins from the B Family. It is also called as Thiamine, Thiamine found in food and also manufactured as a dietary supplement and medication. Food sources of thiamine are whole grains, meats and fish. 90% of Thiamine circulates as TPP (Thiamine pyrophosphate). Thiamine store in skeletal muscles. Thiamine help in the body convert food into energy, and maintain the cardiac system, brain and nerve system healthy.

What is Source of VItamin B1 / Thiamine ?

Source of VItamin B1- Animal Source and Plant Source.
Food source of thiamine include liver, beef, dried milk, oats, nuts, oranges, pork, egg, seeds, legumes, peas and yeast. Rice is source of thiamine. Foods are also fortified with thiamine like rice, pasta, breads and flour.

What is the Characteristics of thiamine ?

Characteristics of thiamine-
Thiamine is a water soluble vitamin, It enables the body to use carbohydrates as energy. It is essential for glucose metabolism, and it plays an important role in nerve, muscle and heart function. Thiamine absorbed mostly in jejunum and ileum of small intestine. It absorb by active transport mechanism.

What is the Function of Thiamine / Vitamin B1 ?

The function of thiamine-
Vitamin B1 plays an important role in metabolism TPP (thiamine pyrophosphate) is essential for oxidation of pyruvate (pyruvic acid) into acetyl COA which is starting production of the krebs cycle. Thiamine helps in maintain the nerve in healthy condition by helping the formation of the myelin sheath. Vitamin B1 is important for nerve transmission of the nerve impulse because it requires the synthesis of neurotransmitters such as Acetylcholine and serotonin.

Thiamine Deficiency disease-

Beri-Beri – its classified in three types

  1. Infantile Beri-Beri
    • Develop with in first six month.
    • lack of thiamine in breast milk. rapid onset.
    • Tachycardia.
    • Labored breath.
    • Depression.
    • Cyanosis.
    • Heart failure.
    • Death.
  2. Wet Beri-Beri
    • Symptom like congestive heart failure.
    • Labored breath.
    • Pitting edema.
    • Fatal circulatory collapse.
    • Depression.
    • Rapidly respond to B1 Supplements.
  3. Dry Beri-Beri.
    • No edema
    • Loss of appetite.
    • Fatigue
    • Numbness, muscles weakness.
    • Chronic infection.
    • Depression.

Wernicke korsakoff Syndrome – (WKS) is a type of brain disorder caused by a lack of vitamin B-1, or thiamine.

Other deficiency symptoms are-fatigue, loss of appetite, irritability, reduced reflexes, tingling sensation in arms and legs, muscles weakness, blurry vision, nausea and vomiting, changing in heart rate, shortness of breath and delirium etc.

Sources and Additional Information:

https://en.wikipedia.org/wiki/Thiamine

http://depressivedisorder.blogspot.com/2012/04/vitamin-b1-thiamine-and-clinical.html